The tumblers on the driver's door on my 91 are worn down and it's getting hard to lock/unlock the door. Gotta find the "sweet spot" for it to work. The passenger door works just fine. Can I just pop the door panels off and swap the lock cylinders? Will that screw up the power door locks?

 

I for one am not thinking it will mess with your power locks...check with Honda if you get crazy about it.
Maybe one of the members might have done this already and can answer it for you..

 

You should be able to do that. You'll have to take apart both doors to remove.

An easier option would be to have a locksmith replace the tumblers in the driver's door lock. See what someone would charge to do the work.